Wilfried Ellmeier

Time-resolved immune dynamics in rheumatoid arthritis under Methotrexate therapy

This study uses scRNA-seq and immunophenotyping to analyze immune changes in RA patients on MTX, showing early restoration of naive T/B cells and reduced memory T cells, with plasmablasts as a potential biomarker.

Candida-Klebsiella interactions rewire fungal morphogenesis to create a host environment favoring pathogen survival with enhanced tissue pathology

This study shows that Candida-Klebsiella interactions enhance fungal virulence and tissue pathology by rewiring fungal morphogenesis and host immune responses.

HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection

This study shows HDAC1 is essential for generating and maintaining CX3CR1+ effector-like T cells during chronic viral infection, which helps control viral load.

HDAC1 acts as tumor suppressor in ALK-positive anaplastic large-cell lymphoma: Implications for HDAC inhibitor therapy

This study shows HDAC1 suppresses ALK-positive lymphoma growth, but systemic HDAC inhibition can still be therapeutic.

Targeting histone acetylation enables epigenetic modulation of inflammatory pathways, a novel therapeutic strategy for rheumatoid arthritis

This study screens histone acetylation inhibitors to modulate immune pathways in RA, showing concentration-dependent effects and overlap with existing RA drug pathways.

Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.

Transcriptional control of adipogenesis by PATZ1

This study identifies PATZ1 as an adipogenic transcription factor that promotes adipogenesis through DNA binding and protein interactions, and its loss protects against diet-induced obesity.

24-Nor-ursodeoxycholic acid counteracts TH17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating TH17 cells

This paper shows that NorUDCA reduces TH17/Treg imbalance and intestinal inflammation by inhibiting glutaminolysis and mTORC1 signaling in TH17 cells.

24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation

This study shows that NorUDCA modulates CD8+ T cell metabolism and function, reducing hepatic inflammation in a mouse model of immune-mediated liver disease.