Lack of p62 impairs glycogen aggregation and exacerbates pathology in a mouse model of myoclonic epilepsy of Lafora
Pasquale Pellegrini, Arnau Hervera, Olga Varea, M. Kathryn Brewer, Iliana López‐Soldado, Anna Guitart-Solanes, Mònica Aguilera, Neus Prats, José Antonio del Rı́o, Joan Josep Guinovart, Jordi Durán
This study shows that p62 is involved in Lafora body formation and that its absence reduces glycogen aggregation in muscle and heart but worsens brain pathology in a mouse model of Lafora disease.
Molecular Neurobiology · Dec 28, 2021Peer-reviewedNeuroscience