Molecular BiologybioRxivPreprint
Stress-induced endogenous-dsRNAs drive beta-cells to IFN-I state
Kevin K. Chi, Parijat Senapati, Amy Leung, Dustin E. Schones
This paper shows proinflammatory cytokine stress increases dsRNA from retrotransposons in beta-cells, leading to an IFN-I state and type 1 diabetes risk.
DOI 10.1101/2023.11.10.566600