Parijat Senapati

The paper identifies distinct mechanisms of enhanced NETosis in type 1 and type 2 diabetes, showing PAD4-independent pathways in T1D and PAD4-dependent pathways in T2D.

This study uses single-cell multi-omics to show that diabetic mice show persistent aortic smooth muscle cell dysfunction and phenotypic changes despite glycemic control, with partial reversal by dapagliflozin.

This study identifies T13F2.2 as a critical gene in C. elegans that affects chromatin structure, autophagy, and lifespan through RNAi depletion and transcriptomic analysis.

This paper shows proinflammatory cytokine stress increases dsRNA from retrotransposons in beta-cells, leading to an IFN-I state and type 1 diabetes risk.

This study shows that glucose-regulated O-GlcNAcylation of DNMT1 inhibits its methyltransferase activity, leading to epigenome changes and increased DNA damage.

This study identifies age-related DNA methylation changes in luminal mammary epithelial cells that correlate with breast cancer methylomes and contribute to lineage fidelity loss.

This study shows hyperinsulinemia increases histone acetylation and promotes tumor growth in TNBC via the PI3K/AKT/mTOR pathway.