Dustin E. Schones

Methylation variability and LINE-1 activation in multiple myeloma

The paper identifies heterogeneous DNA methylation loss and LINE-1 activation in multiple myeloma, linking them to KZFP expression reduction and disease progression.

Stress-induced endogenous-dsRNAs drive beta-cells to IFN-I state

This paper shows proinflammatory cytokine stress increases dsRNA from retrotransposons in beta-cells, leading to an IFN-I state and type 1 diabetes risk.

Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

This study shows that glucose-regulated O-GlcNAcylation of DNMT1 inhibits its methyltransferase activity, leading to epigenome changes and increased DNA damage.

Sequence features of retrotransposons allow for epigenetic variability

The paper identifies sequence features of retrotransposons that influence epigenetic variability in DNA methylation, particularly in IAPs, by affecting KZFP and ZF-CxxC protein interactions.

Regulatory diversity contributes to a divergent transcriptional response to dietary changes in mammals

This study shows that high fat diet-induced transcriptional responses in liver differ between rhesus macaques and mice, with species-specific regulatory elements driving these differences.

Normal mammary epithelia accumulate DNA methylation changes with age that are consistent with breast cancer methylomes

This study identifies age-related DNA methylation changes in luminal mammary epithelial cells that correlate with breast cancer methylomes and contribute to lineage fidelity loss.

Hyperinsulinemia promotes aberrant histone acetylation in triple negative breast cancer

This study shows hyperinsulinemia increases histone acetylation and promotes tumor growth in TNBC via the PI3K/AKT/mTOR pathway.

LTRs activated by Epstein-Barr virus-induced transformation of B cells alter the transcriptome

This study shows that Epstein-Barr virus transforms B cells to activate LTR enhancers and promoters, altering the transcriptome and impacting oncogenic processes.

Chromatin variation associated with liver metabolism is mediated by transposable elements

The paper identifies transposable elements (TEs) as contributors to chromatin accessibility variation in mice liver, linking TE polymorphism and DNA methylation to metabolic pathway differences.