Amy Leung

The paper identifies heterogeneous DNA methylation loss and LINE-1 activation in multiple myeloma, linking them to KZFP expression reduction and disease progression.

This paper shows proinflammatory cytokine stress increases dsRNA from retrotransposons in beta-cells, leading to an IFN-I state and type 1 diabetes risk.

This study shows that glucose-regulated O-GlcNAcylation of DNMT1 inhibits its methyltransferase activity, leading to epigenome changes and increased DNA damage.

The paper identifies sequence features of retrotransposons that influence epigenetic variability in DNA methylation, particularly in IAPs, by affecting KZFP and ZF-CxxC protein interactions.

This study identifies age-related DNA methylation changes in luminal mammary epithelial cells that correlate with breast cancer methylomes and contribute to lineage fidelity loss.

This study shows hyperinsulinemia increases histone acetylation and promotes tumor growth in TNBC via the PI3K/AKT/mTOR pathway.

This study shows that Epstein-Barr virus transforms B cells to activate LTR enhancers and promoters, altering the transcriptome and impacting oncogenic processes.

The paper identifies transposable elements (TEs) as contributors to chromatin accessibility variation in mice liver, linking TE polymorphism and DNA methylation to metabolic pathway differences.