Author

Robert M. Cooper

University of California San DiegoORCID 0000-0003-2136-0403Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Jeff HastyiD· 3 shared Daniel L. WorthleyiD· 1 shared Elaine M. ThomasiD· 1 shared Feargal J. RyaniD· 1 shared Georgette RadfordiD· 1 shared Jarrad M. Goyne· 1 shared Jia Q. NgiD· 1 shared Josephine A. WrightiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSynthetic Biology

Jeff HastyORCID

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Author profile →

3 papers

Recent·Most cited

Engineered bacteria detect tumor DNA

Robert M. Cooper, Josephine A. Wright, Jia Q. Ng, Jarrad M. Goyne, Nobumi Suzuki, Young-Kyung Lee, Mari Ichinose, Georgette Radford, Feargal J. Ryan, Shalni Kumar, Elaine M. Thomas, Laura Vrbanac, Rob D. Knight, Susan Lesley Woods, Daniel L. Worthley, Jeff Hasty

This paper engineers bacteria to detect tumor DNA through horizontal gene transfer, achieving 100% discrimination between mice with and without colorectal cancer.

Science · Aug 10, 2023Peer-reviewedSynthetic Biology

CRISPR-Cas Inhibits Natural Transformation through Altruistic Group Defense and Self-Sacrifice

Robert M. Cooper, Jeff Hasty

The paper investigates how CRISPR-Cas systems in Acinetobacter baylyi inhibit natural transformation through altruistic group defense and self-sacrifice, revealing a trade-off between genetic acquisition and immune defense.

bioRxiv · Sep 16, 2021 · PreprintMolecular Biology

One-Day Construction Of Multiplex Arrays to Harness Natural CRISPR Systems

Robert M. Cooper, Jeff Hasty

The paper presents a rapid, scalable method to construct multiplex natural CRISPR arrays, demonstrating its utility in harnessing the CRISPR system of Acinetobacter baylyi for DNA exclusion and genome editing.

ACS Synthetic Biology · Apr 9, 2020Peer-reviewedSynthetic Biology