VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation
Kyle Mangano, Robert G. Guenette, Spencer Hill, Shiqian Li, Jeffrey J. Liu, Cory M. Nadel, Suresh Archunan, Arghya Sadhukhan, Rajiv Kapoor, Seung Wook Yang, Kate S. Ashton, Patrick Ryan Potts
The paper demonstrates VIPER-TACs, which use viral E3 ligases to selectively degrade disease-specific proteins, reducing toxicity and expanding therapeutic options for targeted protein degradation.
Cell chemical biology · Mar 1, 2025Peer-reviewedCancer Biology