Author

Kyle Mangano

Amgen (United States)ORCID 0000-0001-9862-2374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander S. MankiniD· 1 shared Alexandra BrakeliD· 1 shared Andor Krizsan· 1 shared Arghya Sadhukhan· 1 shared Chetana BaligaiD· 1 shared Cory M. NadeliD· 1 shared Dorota Klepacki· 1 shared Irueosa Ohanmu· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Alexander S. MankinORCID

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2 papers

Recent·Most cited

Cancer BiologyCell chemical biologyPeer-reviewedMar 1, 2025

VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation

Kyle Mangano, Robert G. Guenette, Spencer Hill…·Patrick Ryan Potts

The paper demonstrates VIPER-TACs, which use viral E3 ligases to selectively degrade disease-specific proteins, reducing toxicity and expanding therapeutic options for targeted protein degradation.

14 citations

humanexperimental assay

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Molecular BiologybioRxivPreprintDec 11, 2022

Inhibition of translation termination by Drosocin, an antimicrobial peptide from fruit flies

Kyle Mangano, Dorota Klepacki, Irueosa Ohanmu…·Alexander S. Mankin

This study identifies Drosocin as a type II PrAMP that inhibits protein synthesis termination by stalling ribosomes at stop codons, distinct from apidaecin.

1 citation

Drosophilaproteomics

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