Author

Kate S. Ashton

Amgen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Patrick Ryan PottsiD· 3 shared Shiqian LiiD· 3 shared Arghya Sadhukhan· 2 shared Rajiv Kapoor· 2 shared Robert G. GuenetteiD· 2 shared Suresh Archunan· 2 shared Weixian DengiD· 2 shared Alex Golkar· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

Patrick Ryan PottsORCID

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Author profile →

3 papers

Recent·Most cited

LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation

Dhanusha A. Nalawansha, Georgios Mazis, Gitte Husemoen, Kate S. Ashton, Weixian Deng, Ryan P. Wurz, Anh T. Tran, Brian A. Lanman, Jiansong Xie, Robert G. Guenette, Shiqian Li, Christopher E. Smith, Suresh Archunan, Manoj K. Agnihotram, Arghya Sadhukhan, , Patrick Ryan Potts

This paper introduces LYMTACs, small molecules that use lysosomal membrane proteins to target and degrade membrane proteins, showing effectiveness against KRASG12D.

Nature Communications · Aug 21, 2025Peer-reviewedCancer Biology

Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq

Jonathan W. Bushman, Weixian Deng, Kusal T. G. Samarasinghe, Han‐Yuan Liu, Shiqian Li, Amit Vaish, Alex Golkar, Shu Ou, Jinwoo Ahn, Rajesh K. Harijan, Han Han, Tomas Duffy, Elliot Imler, Judy Qiju Wu, Reneé Rawson, , Patrick Ryan Potts

The paper discovers a VHL molecular glue degrader of GEMIN3 using Picowell RNA-seq screening, showing how it targets GEMIN3 for degradation through ternary complex formation.

bioRxiv · Mar 19, 2025 · PreprintBiochemistry

VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation

Kyle Mangano, Robert G. Guenette, Spencer Hill, Shiqian Li, Jeffrey J. Liu, Cory M. Nadel, Suresh Archunan, Arghya Sadhukhan, Rajiv Kapoor, Seung Wook Yang, Kate S. Ashton, Patrick Ryan Potts

The paper demonstrates VIPER-TACs, which use viral E3 ligases to selectively degrade disease-specific proteins, reducing toxicity and expanding therapeutic options for targeted protein degradation.

Cell chemical biology · Mar 1, 2025Peer-reviewedCancer Biology