Author

Robert G. Guenette

Amgen (United States)ORCID 0000-0002-9057-2031Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Arghya Sadhukhan· 2 shared Kate S. Ashton· 2 shared Patrick Ryan PottsiD· 2 shared Rajiv Kapoor· 2 shared Shiqian LiiD· 2 shared Suresh Archunan· 2 shared Anh T. Tran· 1 shared Brian A. LanmaniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Arghya Sadhukhan

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedAug 21, 2025

LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation

Dhanusha A. Nalawansha, Georgios Mazis, Gitte Husemoen…·Patrick Ryan Potts

This paper introduces LYMTACs, small molecules that use lysosomal membrane proteins to target and degrade membrane proteins, showing effectiveness against KRASG12D.

15 citationstop 5%

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Cancer BiologyCell chemical biologyPeer-reviewedMar 1, 2025

VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation

Kyle Mangano, Robert G. Guenette, Spencer Hill…·Patrick Ryan Potts

The paper demonstrates VIPER-TACs, which use viral E3 ligases to selectively degrade disease-specific proteins, reducing toxicity and expanding therapeutic options for targeted protein degradation.

14 citations

humanexperimental assay

𝕏 PostBluesky