Matthew D. Dun

Preclinical efficacy of combinatorial B7-H3 CAR T cells and ONC206 against diffuse intrinsic pontine glioma

This paper evaluates the combination of B7-H3 CAR T cells and ONC206 against DIPG models, showing enhanced anti-tumor efficacy in vitro and in vivo.

The functional maturation of mouse spermatozoa is underpinned by global remodeling of the cellular phosphoproteome

This study identifies extensive phosphoproteomic remodeling in mouse sperm during maturation and capacitation, revealing key kinases and their roles in fertility.

Mapping Tumor Microenvironment and Treatment Response of Diffuse Midline Glioma Using Multiplexed Immunofluorescence and AI Models

The paper uses multiplexed immunofluorescence and AI models to analyze the tumor microenvironment of diffuse midline glioma and predict antigens from H&E staining.

Sub-chronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice

This study shows that sub-chronic heat stress alters sperm small non-coding RNA profiles in mice, leading to accelerated embryonic development and fetal weight gain.

Adaptive resistance to FLT3 inhibitors is potentiated by ROS-driven DNA repair signalling

This study identifies ATM-driven DNA repair and ROS addiction as mechanisms of resistance to FLT3 inhibitors in AML and shows ATM inhibition can overcome resistance in vitro and in vivo.

SINEultaneous profiling of epigenetic heterogeneity and transcriptome in single cells

The paper introduces scTEM-seq to profile DNA methylation and transcriptomes in single cells, finding DNA methylation heterogeneity linked to gene expression and transposable element activity in AML cells.