Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for AML cell self-renewal.
Danielle R. Bond, Sean M. Burnard, Kumar Uddipto, Kooper V. Hunt, Brooke M. Harvey, Luiza Steffens Reinhardt, Charley Lawlor-O’Neill, Ellise A. Roper, Sam Humphries, Heather C. Murray, Abdul Mannan, Matthew D. Dun, Charles E. de Bock, Nikola A. Bowden, Anoop K. Enjeti, , Heather J. Lee
This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.
bioRxiv · Jan 30, 2024Cancer Biology