This paper evaluates circulating microbial DNA as a cancer biomarker, finding that observed patterns are largely artifacts of sequencing and analysis methods rather than biological signals.

bioRxiv · Aug 20, 2026 · PreprintBioinformatics

Loss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops

Daniel Bsteh, Hagar F. Moussa, Georg Michlits, Ramesh Yelagandula, Jingkui Wang, Ulrich Elling, Oliver Bell

The paper identifies PDS5A as a cohesin regulator linking Polycomb silencing and 3D genome organization, showing that its loss disrupts cohesin activity and Polycomb loops without affecting repressive chromatin marks.

Nature Communications · Dec 9, 2023Peer-reviewedMolecular Biology

REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR

Junghyun L. Suh, Daniel Bsteh, Bryce Hart, Yibo Si, Tyler Weaver, Carina Pribitzer, Roy Lau, Shivani Soni, Heather Anne N. Ogana, Justin M. Rectenwald, Jacqueline L. Norris, Stephanie H. Cholensky, Cari A. Sagum, Jessica M. Umana, Dongxu Li, , Oliver Bell

This paper identifies UNC7040 as a potent CBX8-specific positive allosteric modulator that disrupts PRC1 function and reduces cancer cell proliferation.

Cell chemical biology · Oct 28, 2021Peer-reviewedSynthetic Biology