Oliver Bell

A single epigenetic repressor controls opposing developmental tempos in human neural and cranial neural crest lineages

This study identifies ZNF462 as an epigenetic repressor that controls opposing developmental tempos in human neural and cranial neural crest lineages by regulating lineage-specific enhancers.

Loss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops

The paper identifies PDS5A as a cohesin regulator linking Polycomb silencing and 3D genome organization, showing that its loss disrupts cohesin activity and Polycomb loops without affecting repressive chromatin marks.

REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR

This paper identifies UNC7040 as a potent CBX8-specific positive allosteric modulator that disrupts PRC1 function and reduces cancer cell proliferation.

ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes

This study identifies ZFP462's role in restricting endodermal gene expression by targeting transposon-derived enhancers and modulating histone methylation in mouse embryonic stem cells.

Nucleosome turnover is sufficient to establish varied histone methylation states

This study shows that nucleosome turnover can establish varied H3K79 methylation states without active demethylation.