Author

Iris N. Farnum

Massachusetts General HospitalORCID 0000-0003-2189-4579Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adam M. CoombsiD· 1 shared Ben EmeryiD· 1 shared Benjamin P. KleinstiveriD· 1 shared Dadi GaoiD· 1 shared Diane E. LucenteiD· 1 shared Elisabetta MoriniiD· 1 shared James F. GusellaiD· 1 shared Jayla Ruliera· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Adam M. CoombsORCID

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2 papers

Recent·Most cited

NeuroscienceJournal of NeurosciencePeer-reviewedApr 7, 2026

Temporal Requirement for Stearoyl-CoA Desaturase 1 in Oligodendrocyte Development but Not Myelin Maintenance

Iris N. Farnum, Thaddeus J. Kunkel, Adam M. Coombs…·Manideep Chavali

This study shows that Scd1 is required for oligodendrocyte development and myelination but not for maintaining mature myelin.

DOI 10.1523/jneurosci.1881-25.2026

mouseexperimental assay

GeneticsNature CommunicationsPeer-reviewedApr 12, 2024

PMS1 as a target for splice modulation to prevent somatic CAG repeat expansion in Huntington's disease

Zachariah L. McLean, Dadi Gao, Kevin Correia…·James F. Gusella

This study shows splice modulators like branaplam reduce HTT CAG repeat expansion by affecting PMS1 expression, suggesting PMS1 as a new therapeutic target for Huntington's disease.

48 citationstop 1%

humanexperimental assay