Ben Emery

Myelin maintenance and addition regulate synaptic plasticity in the adult mouse cortex

This study shows that myelin maintenance in adult mice affects synaptic plasticity and neuron homeostasis, while new myelin stabilizes synapses in basal dendrites.

PIEZOs regulate oligodendrocyte sheath formation, expansion, and myelination potential

This study shows that PIEZO1 and PIEZO2 channels in oligodendrocytes regulate sheath formation, expansion, and myelination by detecting mechanical cues.

Temporal Requirement for Stearoyl-CoA Desaturase 1 in Oligodendrocyte Development but Not Myelin Maintenance

This study shows that Scd1 is required for oligodendrocyte development and myelination but not for maintaining mature myelin.

Activation of cannabinoid receptor CB1 leads to aberrant myelination in development

This study shows that activating CB1 receptors in zebrafish leads to increased non-axonal ensheathment without affecting OL differentiation or normal myelin formation.

Astrocyte gap junctions and Kir channels contribute to K+ buffering and regulate neuronal excitability

This study investigates the role of astrocyte gap junctions and Kir channels in K+ buffering and neuronal excitability by blocking these mechanisms in cortical slices.

TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination

This study identifies TMEM63A as a critical regulator of myelination in the CNS, showing its role in oligodendrocyte function and linking its dysfunction to hypomyelinating leukodystrophies.

Distinct cell types along thick ascending limb express pathways for monovalent and divalent cation transport

The paper identifies three distinct cell types in thick ascending limb cells across species, each with unique potassium channel and claudin expression patterns that influence cation transport.

Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes

This study shows that CNS axon diameter growth does not require oligodendrocyte ensheathment or myelination, contrasting with PNS findings.

Remyelination protects neurons from DLK-mediated neurodegeneration

This study shows that remyelination protects neurons from DLK-mediated neurodegeneration by preventing apoptosis and inflammation in a mouse model of demyelination.

FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS

This study identifies FBXW7 as a regulator of myelin capacity and homeostasis in the adult CNS by controlling MYRF levels through ubiquitination.

Myelin and nodal plasticity modulate action potential conduction in the adult mouse brain

The paper shows that mature myelin in adult mice is plastic and can modify node of Ranvier length and periaxonal space size to adjust action potential conduction velocity and synchronicity.

Thyroid hormone and thyromimetics inhibit myelin and axonal degeneration and oligodendrocyte loss in EAE

This study shows that thyroid hormone and thyromimetics reduce disease severity and protect oligodendrocytes in EAE by decreasing myelin and axonal degeneration.