Adam M. Coombs

This study shows that PIEZO1 and PIEZO2 channels in oligodendrocytes regulate sheath formation, expansion, and myelination by detecting mechanical cues.

This study shows that Scd1 is required for oligodendrocyte development and myelination but not for maintaining mature myelin.

This study identifies TMEM63A as a critical regulator of myelination in the CNS, showing its role in oligodendrocyte function and linking its dysfunction to hypomyelinating leukodystrophies.

This study identifies heterozygous TMEM63A variants causing transient hypomyelination in infancy, with clinical improvement over time.