Author

Maria‐Daniela Cirnaru

Icahn School of Medicine at Mount SinaiORCID 0000-0003-2202-4284Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Ali Moussavi NikiD· 1 shared Alice Biosa· 1 shared Azadeh Reyahi· 1 shared Carlos Galicia AguirreiD· 1 shared Chuhyon CorwiniD· 1 shared Elisa GreggioiD· 1 shared Francesca PischeddaiD· 1 shared Giovanni PiccoliiD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Ali Moussavi NikORCID

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2 papers

Recent·Most cited

NeuroscienceeLifePeer-reviewedOct 5, 2021

Transcriptional and epigenetic characterization of early striosomes identifies Foxf2 and Olig2 as factors required for development of striatal compartmentation and neuronal phenotypic differentiation

Maria‐Daniela Cirnaru, Sicheng Song, Kizito‐Tshitoko Tshilenge…·Michelle E. Ehrlich

The paper identifies Foxf2 and Olig2 as key transcription factors regulating striatal compartmentation and neuronal differentiation through RNA- and ATAC-seq analysis of murine striosomes and matrix.

19 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeuroscienceBrainPeer-reviewedFeb 26, 2021

LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation

Francesca Pischedda, Maria‐Daniela Cirnaru, Luisa Ponzoni…·Giovanni Piccoli

This study shows that LRRK2 G2019S kinase activity promotes NSF aggregation, which is toxic to neurons, and that autophagy can clear these aggregates and improve motor and cognitive function in a mouse model.

33 citations

mouseexperimental assay

𝕏 PostBluesky