Author

Francesca Pischedda

University of TrentoORCID 0000-0003-2006-2607Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Elisa GreggioiD· 2 shared Giovanni PiccoliiD· 2 shared Rina BandopadhyayiD· 2 shared Algerta MarkuiD· 1 shared Alice Biosa· 1 shared Angela Di IacovoiD· 1 shared Antonella MarteiD· 1 shared Carla PeregoiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Elisa GreggioORCID

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2 papers

Recent·Most cited

NeuroscienceActa NeuropathologicaPeer-reviewedMay 21, 2022

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease

Ludovica Iovino, Veronica Giusti, Francesca Pischedda…·Laura Civiero

This study shows that the LRRK2 G2019S mutation impairs EAAT2 trafficking, leading to reduced glutamate clearance and potential neurodegeneration in Parkinson's disease.

65 citationstop 3%

humanmouse

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NeuroscienceBrainPeer-reviewedFeb 26, 2021

LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation

Francesca Pischedda, Maria‐Daniela Cirnaru, Luisa Ponzoni…·Giovanni Piccoli

This study shows that LRRK2 G2019S kinase activity promotes NSF aggregation, which is toxic to neurons, and that autophagy can clear these aggregates and improve motor and cognitive function in a mouse model.

33 citations

mouseexperimental assay

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