LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation
Francesca Pischedda, Maria‐Daniela Cirnaru, Luisa Ponzoni, Michele Sandre, Alice Biosa, María Dolores Pérez‐Carrión, Oriano Marin, Michele Morari, Lifeng Pan, Elisa Greggio, Rina Bandopadhyay, Mariaelvina Sala, Giovanni Piccoli
This study shows that LRRK2 G2019S kinase activity promotes NSF aggregation, which is toxic to neurons, and that autophagy can clear these aggregates and improve motor and cognitive function in a mouse model.
Brain · Feb 26, 2021Peer-reviewedNeuroscience