Luisa Ponzoni

Hippocampal Ring Finger Protein 10-dependent signaling supports cognitive flexibility

This study identifies RNF10-mediated signaling in the dorsal hippocampus as essential for cognitive flexibility by linking NMDAR activation to transcriptional programs that support adaptive behavior.

Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eEF2K

This study shows that inhibiting eEF2K reduces seizures and behavioral issues in a Dravet syndrome mouse model by enhancing GABAergic transmission.

Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures

This study shows that deleting calcineurin in astrocytes leads to proteome changes resembling Alzheimer's and epilepsy, and increases seizure risk in mice.

LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation

This study shows that LRRK2 G2019S kinase activity promotes NSF aggregation, which is toxic to neurons, and that autophagy can clear these aggregates and improve motor and cognitive function in a mouse model.