Jefferson D. Knight

This study identifies protein carbonylation as a mechanism by which inflammatory oxidative stress inhibits insulin secretion in pre-type 1 diabetes.

This study investigates how Syt-7 C2 domains generate membrane curvature through electrostatic interactions and the wedge mechanism, using simulations and assays.

The paper uses molecular phylogenetic analysis and homology modeling to show that the electrostatic membrane-binding surface of synaptotagmin-like proteins is highly conserved across vertebrates.

This study compares the membrane-binding behavior of C2AB tandem domains in synaptotagmin-1 and -7, showing cooperative binding in Syt-1 and lack thereof in Syt-7.