H. Tran

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

This study shows that plasmacytoid dendritic cells (pDCs) and their interferons are dispensable or harmful in systemic and respiratory viral infections in mice.

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

This study develops and tests EREG-targeting ADCs showing efficacy in both RAS mutant and wildtype CRC, with high potency and safety in preclinical models.

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

This study identifies Trabid mutations that disrupt APC trafficking and neurite growth by impairing DUB activity or STRIPAK binding, leading to neurodevelopmental defects.

Light-induced nanoscale deformation in azobenzene thin film triggers rapid intracellular Ca2+ increase via mechanosensitive cation channels

The paper uses light-induced nanoscale deformation of azobenzene thin films to study mechanosensitive Ca2+ signaling in cells, identifying Piezo1 as the key channel involved.

The mobility of the cap domain is essential for the substrate promiscuity of a family IV esterase from sorghum rhizosphere microbiome

This paper identifies and characterizes a novel esterase from the Sorghum bicolor rhizosphere microbiome, revealing that its cap domain mobility enables broad substrate promiscuity despite a narrow catalytic tunnel.

In vitro screening of herbal medicinal products for their supportive curing potential in the context of SARS-CoV-2

This study screens five herbal extracts for their potential to inhibit SARS-CoV-2 Spike-ACE2 interaction and modulate immune responses in vitro.

In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose

The paper shows that Bax-/-Bak1-/- myeloid cells deprived of IL3 survive by consuming extracellular glucose, without needing Atg5-dependent autophagy.

Precision in a rush: trade-offs between reproducibility and steepness of the hunchback expression pattern

The paper examines how short developmental cycles affect the precision and reproducibility of hunchback gene expression patterns in flies.