L. Anderson

Nature Forest Reserves in Tanzania and their importance for conservation

This paper assesses the expansion and conservation impact of Tanzania's Nature Forest Reserves, showing increased coverage of habitats and species, but ongoing threats remain.

ROCK2 Knockout Improves Proliferation Rate in a Cellular Model of Down Syndrome

ROCK2 knockout improves cell proliferation in a trisomy 21 cellular model of Down Syndrome, with no effect in euploid cells.

DSS-induced inflammation in the colon drives a pro-inflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod

This study shows that colonic inflammation from DSS induces a pro-inflammatory brain signature, which is reduced by S100A9 inhibitor paquinimod.

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

Metaplasia of respiratory and digestive tissues in the Eastern oyster Crassostrea virginica associated with the Deepwater Horizon oil spill

The paper documents metaplasia in wild eastern oysters from the Gulf of Mexico post-Deepwater Horizon oil spill, showing higher rates than Chesapeake Bay controls.

TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells

This study shows that TWIST1 regulates senescence and metabolism in human mesenchymal stem cells, with TWIST1 silencing inducing a distinct SASP and metabolic profile compared to irradiation-induced senescence.

Organ-on-a-chip model of vascularized human bone marrow niches

This study develops a 3D organ-on-a-chip model of human bone marrow niches that supports hematopoietic stem cell maintenance, differentiation, and myeloid progenitor egress.

Cooperativity and Avidity in Membrane Binding by C2AB Tandem Domains of Synaptotagmins 1 and 7

This study compares the membrane-binding behavior of C2AB tandem domains in synaptotagmin-1 and -7, showing cooperative binding in Syt-1 and lack thereof in Syt-7.