Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor (ETI) suggest benefits beyond improved CFTR channel function
Thomas H. Hampton, Roxanna Barnaby, Carolyn Roche…·Bruce A. Stanton
This study shows ETI increases defensin gene expression and reduces MMP10, MMP12, and inflammatory signaling in CF airway epithelial cells.