Roxanna Barnaby

Polymicrobial extracellular vesicles reduce the innate immune response of human cystic fibrosis bronchial epithelial cells

This paper shows polymicrobial extracellular vesicles enhance virulence and inflammation in CF bronchial epithelial cells, and modulator therapy ETI does not reverse this effect.

Outer Membrane Vesicles Secreted by Bacteroides fragilis Inhibit CFTR Chloride Secretion by Human Colon Organoids

This study shows that Bacteroides fragilis outer membrane vesicles reduce CFTR Cl- secretion in human colon organoids, with BFT-2-containing vesicles being more effective.

Extracellular Particles Derived from Mesenchymal Stromal Cells Reduce Pseudomonas aeruginosa Lung Infection and Inflammation in Mice

This study shows that mesenchymal stromal cell-derived extracellular particles reduce Pseudomonas aeruginosa lung infection and inflammation in a cystic fibrosis mouse model.

Let-7b-5p loaded Mesenchymal Stromal Cell Extracellular Vesicles reduce Pseudomonas- biofilm formation and inflammation in CF Bronchial Epithelial Cells

This paper shows that let-7b-5p-loaded MSC EVs block antibiotic-resistant P. aeruginosa biofilm formation and reduce inflammation in CF bronchial epithelial cells.

Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor (ETI) suggest benefits beyond improved CFTR channel function

This study shows ETI increases defensin gene expression and reduces MMP10, MMP12, and inflammatory signaling in CF airway epithelial cells.