Author

Carolyn Roche

Dartmouth College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Bruce A. StantoniD· 4 shared Roxanna Barnaby· 4 shared Byoung-Kyu ChoiD· 3 shared Douglas J. TaatjesiD· 3 shared Lily A. CharpentieriD· 3 shared Thomas H. HamptoniD· 3 shared Young Ah GooiD· 3 shared Amanda B. Nymon· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersMicrobiology

Bruce A. StantonORCID

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Author profile →

4 papers

Recent·Most cited

Polymicrobial extracellular vesicles reduce the innate immune response of human cystic fibrosis bronchial epithelial cells

Lily A. Charpentier, Roxanna Barnaby, Carolyn Roche, Byoung-Kyu Cho, Prashant Kaushal, Young Ah Goo, Brad Vietje, Douglas J. Taatjes, Alix Ashare, Fabrice Jean-Pierre, Bruce A. Stanton

This paper shows polymicrobial extracellular vesicles enhance virulence and inflammation in CF bronchial epithelial cells, and modulator therapy ETI does not reverse this effect.

Journal of Extracellular Biology · Aug 1, 2026Peer-reviewedMicrobiology

Outer Membrane Vesicles Secreted by Bacteroides fragilis Inhibit CFTR Chloride Secretion by Human Colon Organoids

Roxanna Barnaby, Amanda B. Nymon, Paige Salerno, Carolyn Roche, Young Ah Goo, Byoung-Kyu Cho, Timothy B. Gardner, Zdeněk Švindrych, Douglas J. Taatjes, Thomas H. Hampton, Benjamin D. Ross, Bruce A. Stanton

This study shows that Bacteroides fragilis outer membrane vesicles reduce CFTR Cl- secretion in human colon organoids, with BFT-2-containing vesicles being more effective.

Infection and Immunity · May 29, 2026Peer-reviewedMicrobiology

Extracellular Particles Derived from Mesenchymal Stromal Cells Reduce Pseudomonas aeruginosa Lung Infection and Inflammation in Mice

Sharanya Sarkar, Roxanna Barnaby, Zachary J. Faber, Lily D. Taub, Carolyn Roche, Lily A. Charpentier, Thomas H. Hampton, Brad Vietje, Douglas J. Taatjes, Byoung-Kyu Cho, Young Ah Goo, Matthew J. Wargo, Dj Weiss, Tracey L. Bonfield, T. Kelley, Bruce A. Stanton

This study shows that mesenchymal stromal cell-derived extracellular particles reduce Pseudomonas aeruginosa lung infection and inflammation in a cystic fibrosis mouse model.

Journal of Extracellular Biology · Feb 1, 2026Peer-reviewedMicrobiology

Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor (ETI) suggest benefits beyond improved CFTR channel function

Thomas H. Hampton, Roxanna Barnaby, Carolyn Roche, Amanda B. Nymon, Kiyoshi F. Fukutani, Todd A. MacKenzie, Lily A. Charpentier, Bruce A. Stanton

This study shows ETI increases defensin gene expression and reduces MMP10, MMP12, and inflammatory signaling in CF airway epithelial cells.

American Journal of Physiology-Lung Cellular and Molecular Physiology · Oct 22, 2024Peer-reviewedPharmacology & Toxicology