Bruce A. Stanton

This paper shows polymicrobial extracellular vesicles enhance virulence and inflammation in CF bronchial epithelial cells, and modulator therapy ETI does not reverse this effect.

This study shows that Bacteroides fragilis outer membrane vesicles reduce CFTR Cl- secretion in human colon organoids, with BFT-2-containing vesicles being more effective.

This study shows that mesenchymal stromal cell-derived extracellular particles reduce Pseudomonas aeruginosa lung infection and inflammation in a cystic fibrosis mouse model.

This paper shows that let-7b-5p-loaded MSC EVs block antibiotic-resistant P. aeruginosa biofilm formation and reduce inflammation in CF bronchial epithelial cells.

This study shows ETI increases defensin gene expression and reduces MMP10, MMP12, and inflammatory signaling in CF airway epithelial cells.

E.PathDash provides a tool for analyzing gene expression data from pathogens, enabling rapid pathway activation analysis and reproducibility assessment across multiple studies.

This paper shows tobramycin reduces inflammation in cystic fibrosis by increasing 5' tRNA-fMet halves in P. aeruginosa outer membrane vesicles, which suppress IL-8 and neutrophilic inflammation in human cells and mice.

Rocket-miR predicts human miRNA interactions with pathogens to identify potential antimicrobial candidates against antibiotic-resistant infections.

CF-Seq provides a web tool for re-analyzing CF pathogen RNA-seq data, enabling efficient filtering, visualization, and hypothesis generation across multiple studies.