Ryo Hatori

The paper investigates protein turnover and intracellular trafficking of Hedgehog signaling components in Drosophila wing discs and finds that Smoothened's distribution and half-life are regulated by Hedgehog signaling.

The paper shows that the extent of Hh, Wg, and Dpp signaling is independent of signal production levels or recipient cell numbers.

The paper shows that Hedgehog from the Drosophila wing imaginal disc induces distinct gene expression responses in three target tissues through cytoneme-mediated signaling.