Thomas B. Kornberg

Heparan sulfate is essential for Drosophila FGF export

The paper shows that heparan sulfate proteoglycans are essential for exporting Drosophila FGF ortholog Branchless to the cell surface.

Smoothened turnover regulated by Hedgehog signaling in Drosophila

The paper investigates protein turnover and intracellular trafficking of Hedgehog signaling components in Drosophila wing discs and finds that Smoothened's distribution and half-life are regulated by Hedgehog signaling.

High-Resolution, Large Imaging Volume, and Multi-View Single Objective Light-Sheet Microscopy

This paper introduces a novel single objective light-sheet microscope that achieves high resolution, large field of view, and multi-view imaging for various biological systems.

Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

Regulated delivery controls Drosophila Hedgehog, Wingless and Decapentaplegic signaling

The paper shows that the extent of Hh, Wg, and Dpp signaling is independent of signal production levels or recipient cell numbers.

Fusion of Drosophila oocytes with specified germline sister cells

The paper describes the fusion of specific Drosophila nurse cells with the oocyte and its implications for oocyte development.

Hedgehog produced by the Drosophila wing imaginal disc induces distinct expression responses in three target tissues

The paper shows that Hedgehog from the Drosophila wing imaginal disc induces distinct gene expression responses in three target tissues through cytoneme-mediated signaling.

Glutamate signaling at cytoneme synapses

The paper shows that cytoneme-mediated signaling in Drosophila air sac primordium is glutamatergic, requiring GluRII and calcium transients.