Utpal Das

This study shows that phosphorylation of α-synuclein at Serine-129 is a physiologic trigger for protein interactions and synaptic function, challenging its previous association with pathology.

The paper investigates the mechanisms and organization of clathrin transport and presynaptic targeting in neurons, revealing stable transport-packets and their role in synaptic clathrin organization.

This paper introduces a CRISPR/Cas9 strategy to edit APP and manipulate the amyloid pathway in Alzheimer's disease by reducing β-cleavage and Aβ while increasing α-cleavage.