Author

Amanda M. Snead

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrew A. SprouliD· 2 shared Andrew DobriaiD· 1 shared Andrew J. PeterseniD· 1 shared Anita BhattacharyyaiD· 1 shared Camerron M. CrowderiD· 1 shared Cristina Guardia‐LaguartaiD· 1 shared Delfina LarreaiD· 1 shared Diya Dileep· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Andrew A. SproulORCID

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Author profile →

3 papers

Recent·Most cited

Small molecule modulator of neuronal lysosome positioning and function resolves Alzheimers Disease-linked pathologies in cultured human neurons

Amanda M. Snead, Sruchi Patel, Mia Krout, Ryan S. Hippman, Gabrielle Smith, Diya Dileep, Nitya Chagoor, Rachel Shi, Ricardo Linares-Saldana, Andrew Dobria, Stephanie M. Cologna, Camerron M. Crowder, Leslie N. Aldrich, Swetha Gowrishankar

A small molecule modulates neuronal lysosome positioning and function, reducing amyloid-beta levels and rescuing pathologies in human neurons and zebrafish.

bioRxiv · Nov 4, 2024 · PreprintCell Biology

THE C99 FRAGMENT OF APP REGULATES CHOLESTEROL TRAFFICKING

Marta Pera, Delfina Larrea, Jorge Montesinos, Cristina Guardia‐Laguarta, Rishi R. Agrawal, KEVIN R. VELASCO, Yimeng Xu, SY Koo, Amanda M. Snead, Andrew A. Sproul, Estela Área-Gómez

This study shows that the C99 fragment of APP regulates cholesterol trafficking between the plasma membrane and ER, contributing to AD pathogenesis.

bioRxiv · Aug 21, 2019 · PreprintMolecular Biology

A CRISPR/Cas9 based strategy to manipulate the Alzheimer’s amyloid pathway

Jichao Sun, Jared Carlson-Stevermer, Utpal Das, Minjie Shen, Marion Delenclos, Amanda M. Snead, Lina Wang, Jonathan Loi, Andrew J. Petersen, Michael E. Stockton, Anita Bhattacharyya, Mathew V. Jones, Andrew A. Sproul, Pamela J. McLean, Xinyu Zhao, , Subhojit Roy

This paper introduces a CRISPR/Cas9 strategy to edit APP and manipulate the amyloid pathway in Alzheimer's disease by reducing β-cleavage and Aβ while increasing α-cleavage.

bioRxiv · Apr 28, 2018 · PreprintNeuroscience