Thomas C. A. Hitch

This study identifies a bacterial protease that influences phage susceptibility and links it to host epithelial responses in ulcerative colitis.

This study shows that mixed acid fermentation products from Lachnospira eligens counteract myotube atrophy and links reduced gut anaerobiosis in AML patients to decreased muscle strength.

This paper introduces a robust method for bacterial genus classification using POCPu, showing it outperforms traditional POCP calculations.

The paper proposes a roadmap for fair reuse of public microbiome data by introducing a Data Reuse Information tag (DRI) to facilitate communication between data creators and consumers.

The paper establishes a publicly available collection of 340 human gut bacterial strains, including 29 newly described species, and identifies plasmids and megaplasmids within these isolates.

The paper develops a lineage-specific gene prediction method for metagenomic data, improving protein prediction accuracy and enabling functional analysis of the human gut microbiome.

This study benchmarks shotgun sequencing depth in metagenomics, showing that strain-level analysis and functional insights require deep sequencing, while shallow sequencing has significant limitations.

The paper develops a method to design synthetic microbial communities based on metagenomic data, demonstrating its ability to model disease-associated microbiomes.