Gut microbiota-dependent phenylpropanoic acid derivatives reduced in cancer cachexia protect against myotube atrophy
Alexandra L. Degraeve, Xiaolin Li, Camille Lefevre, Edwige Piron, Axelle E. Loriot, Nathalie M. Delzenne, Audrey M. Neyrinck, Laure B. Bindels
The paper identifies gut microbiota-derived metabolites that protect against muscle atrophy in cancer cachexia by restoring amino acid homeostasis through the serine biosynthesis pathway.
bioRxiv · Sep 18, 2026 · PreprintMicrobiology