Randal S. Tibbetts

The paper identifies an exitron in UBQLN2 that generates an alternatively spliced isoform with distinct properties linked to ALS.

This study shows DNA damage induces alternative splicing of RIF1, generating isoforms that affect DNA repair complex assembly and phase separation.

The paper identifies BAG6 as a suppressor of UBQLN2 misfolding in ALS-dementia by analyzing interactome changes in mutant UBQLN2 proteins.

This study identifies axon guidance pathways as modulators of UBQLN2 toxicity in ALS/FTD, showing reduced neurodegeneration with UNC5B and DCC suppression in multiple models.

This study identifies FUS's role in DNA replication timing and progression, showing its importance in genome stability and its potential contribution to disease.