Matthew P. Wilson

This study identifies two yeast enzymes, Env9 and Tda5, that perform distinct steps in dolichol biosynthesis, replacing the dual role of DHRSX in humans.

This study identifies DHRSX gene absence as the cause of dolichol synthesis defect in Lec5 and Lec9 CHO cells, correcting N-glycosylation defects through DHRSX complementation.

This study shows N-glycosylation prevents protein aggregation by steric hindrance, especially in proteins prone to misfolding, using computational and biochemical analyses.