Author

Francesco Caligiore

de Duve InstituteORCID 0000-0002-4038-3136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Guido T. BommeriD· 2 shared Ayşegül Erdem· 1 shared Céline SchulziD· 1 shared Charlotte R. AlthoffiD· 1 shared E. Pieters· 1 shared Emile VAN SCHAFTINGENiD· 1 shared Erika L. SoucheiD· 1 shared Fleur Leguay· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Guido T. BommerORCID

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2 papers

Recent·Most cited

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival

Ayşegül Erdem, Séléna Kaye, Francesco Caligiore, Manuel Johanns, Fleur Leguay, Jan Jacob Schuringa, Keisuke Ito, Guido T. Bommer, Nick van Gastel

This study shows that LDHA is essential for maintaining NAD+/NADH balance in AML cells, and its inhibition leads to cell death, suggesting it as a therapeutic target.

Cancer & Metabolism · May 19, 2025Peer-reviewedCancer Biology

The N-glycosylation defect in Lec5 and Lec9 CHO cells is caused by absence of the DHRSX gene

Takfarinas Kentache, Charlotte R. Althoff, Francesco Caligiore, Erika L. Souche, Céline Schulz, Julie Graff, E. Pieters, Pamela Stanley, Joseph N. Contessa, Emile VAN SCHAFTINGEN, Gert Matthijs, François Foulquier, Guido T. Bommer, Matthew P. Wilson

This study identifies DHRSX gene absence as the cause of dolichol synthesis defect in Lec5 and Lec9 CHO cells, correcting N-glycosylation defects through DHRSX complementation.

Journal of Biological Chemistry · Oct 10, 2024Peer-reviewedBiochemistry