Author

Candilianne Serrano-Zayas

Howard Hughes Medical InstituteORCID 0000-0003-1192-1879Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brian T. EmmeriD· 2 shared David GinsburgiD· 1 shared Donna M. MartiniD· 1 shared Jennifer M. SkidmoreiD· 1 shared Kyle LeixiD· 1 shared Matthew L. HoldingiD· 1 shared Sarah E. GrahamiD· 1 shared Taslima Gani KhaniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Brian T. EmmerORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintMar 20, 2025

Functional interrogation of candidate cis-regulatory elements at the LDLR locus

Kyle Leix, Candilianne Serrano-Zayas, Sarah E. Graham, Brian T. Emmer

The paper uses CRISPR screening to identify a functional enhancer in the first intron of LDLR that influences LDL uptake and is associated with LDL cholesterol levels.

DOI 10.1101/2025.03.20.644385

humanCRISPR screen

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Molecular BiologybioRxivPreprintSep 20, 2022

Regulation of cellular LDL uptake by PROX1 and CHD7

Candilianne Serrano-Zayas, Matthew L. Holding, Taslima Gani Khan…·Brian T. Emmer

This study identifies PROX1 and CHD7 as regulators of LDL uptake, with PROX1 directly enhancing LDLR expression and CHD7 acting through an LDLR-independent mechanism.

1 citation

humanexperimental assay

𝕏 PostBluesky