ImmunologybioRxivPreprint
Overcoming immune evasion from post-translational modification of a mutant KRAS epitope to achieve TCR-T cell-mediated antitumor activity
Jihoon William Lee, Emily Y. Chen, Taylor Hu…·Philip D. Greenberg
Tumor cell methylation of KRASG12V epitope in HLA-A2 permits immune evasion, and new TCRs were generated to overcome this with engineered cell therapy.
DOI 10.1101/2024.09.18.612965