Philip D. Greenberg

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

The paper profiles CD8+ T cells in multiple myeloma patients to assess tumor reactivity and exhaustion, finding no evidence of tumor-experienced T cells with hallmark exhaustion or activation features.

APMAT analysis links CD8 T cell receptors, cognate antigens, and T cell phenotype/persistence using integrated experimental-computational methods.

The paper identifies JCV VP1 epitopes recognized by HLA-A2 and isolates TCRs that recognize these epitopes, showing cytotoxic activity against infected cells.

Tumor cell methylation of KRASG12V epitope in HLA-A2 permits immune evasion, and new TCRs were generated to overcome this with engineered cell therapy.