Overcoming immune evasion from post-translational modification of a mutant KRAS epitope to achieve TCR-T cell-mediated antitumor activity
Jihoon William Lee, Emily Y. Chen, Taylor Hu, Rachel Perret, Mary E. Chaffee, Tijana Martinov, Shwetha Mureli, Clara McCurdy, Lisa Anne Jones, Philip R. Gafken, Pritha Chanana, Yapeng Su, Aude G. Chapuis, Philip H Bradley, Thomas M. Schmitt, Philip D. Greenberg
Tumor cell methylation of KRASG12V epitope in HLA-A2 permits immune evasion, and new TCRs were generated to overcome this with engineered cell therapy.
bioRxiv · Sep 18, 2024 · PreprintImmunology