Scott A. Berceli

This study shows that intramuscular adipose tissue (IMAT) accumulation worsens limb function in PAD/CLTI, and reducing IMAT improves muscle strength and work output in mice.

The paper uses single nuclei RNA sequencing to analyze muscle from PAD patients and controls, identifying transcriptional changes and cell type alterations associated with the disease.

This paper introduces a framework to infer dynamic, personalized gene regulatory networks from transcriptional data and applies it to study surgical outcomes in a clinical genomic study.