Intramuscular Adipose Tissue Accumulation is a Key Determinant of Limb Function in Peripheral Artery Disease
Victoria R. Palzkill, Divyansha Moparthy, Qingping Yang, Jaewon Choi, Xinyue Liu, Kyoungrae Kim, Ambili Bai Appu, Caroline G. Pass, Scott A. Berceli, Curt D. Sigmund, Salvatore T. Scali, Daniel Kopinke, TERENCE EDWARD RYAN
This study shows that intramuscular adipose tissue (IMAT) accumulation worsens limb function in PAD/CLTI, and reducing IMAT improves muscle strength and work output in mice.
Circulation · Mar 10, 2026Peer-reviewedPhysiology