Chandramouli Muralidharan

This study reprograms human dental pulp stem cells into neurons more rapidly and efficiently than fibroblasts, using a lentiviral vector and single-nucleus RNA sequencing to characterize the process.

The paper identifies phosphoproteomic changes in Huntington's disease patient-derived neurons, revealing dysregulated post-translational modifications and potential compensatory mechanisms.

This study identifies a chimpanzee-specific retroviral insertion that influences gene regulation and brain development, highlighting its role in human-chimpanzee brain divergence.

The paper develops cell-type-specific transcriptomic aging clocks using single-nuclei RNA sequencing data from human prefrontal cortex tissue, showing distinct aging patterns across cell types.