Fbxw7 is a critical regulator of Schwann cell myelinating potential
Breanne L. Harty, Fernanda Matos Coelho, Sarah E. Pease-Raissi, Amit Mogha, Sarah D. Ackerman, Amy L Herbert, Robert W. Gereau, Judith P. Golden, David Anthony Lyons, Jonah R. Chan, Kelly R. Monk
This study shows that Fbxw7 loss enhances Schwann cell myelinating potential by altering mTOR signaling and enabling multiple axon myelination, challenging previous distinctions between myelinating and non-myelinating Schwann cells.
Nature Communications · Jul 5, 2019Peer-reviewedNeuroscience