Jonah R. Chan

Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

This study shows that preventing oligodendrocyte maturation during adolescence reduces myelination and preserves experience-dependent plasticity in adult visual cortex.

Minimum Effective Dose of Clemastine in a Mouse Model of Preterm White Matter Injury

Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response

This study investigates how combining Sephin1 and BZA accelerates remyelination under inflammation by modulating the integrated stress response in oligodendrocytes.

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

This study shows that enhancing the integrated stress response (ISR) improves remyelination in inflammatory CNS lesions in mice.

Fbxw7 is a critical regulator of Schwann cell myelinating potential

This study shows that Fbxw7 loss enhances Schwann cell myelinating potential by altering mTOR signaling and enabling multiple axon myelination, challenging previous distinctions between myelinating and non-myelinating Schwann cells.