Sarah D. Ackerman

A CRISPR/Cas9 screen reveals convergent dysregulation of neurological pathways within and across glycosylation pathways

The paper uses CRISPR/Cas9 to knockdown glycosylation genes in zebrafish, revealing shared neurological dysregulation across CDG classes through RNA sequencing and behavioral assays.

A Drosophila glial cell atlas reveals a mismatch between detectable transcriptional diversity and morphological diversity

The paper generates a Drosophila glial cell atlas and finds that transcriptional diversity does not match morphological diversity across glial classes.

Activity-dependent mitochondrial transport in peri-synaptic glia drives motor function

The paper shows that astrocytes transfer mitochondria to neurons during activity to support metabolic needs, and disrupting this process causes motor deficits.

Astrocytes close a critical period of motor circuit plasticity

The paper identifies astrocytes as essential for closing the critical period of motor circuit plasticity in Drosophila by regulating dendrite morphology and locomotor behavior through Neuroligin-Neurexin signaling.

Postembryonic screen for mutations affecting spine development in zebrafish

This study identifies mutations affecting spine development in zebrafish, revealing new candidate genes for human spine disorders like scoliosis.

Fbxw7 is a critical regulator of Schwann cell myelinating potential

This study shows that Fbxw7 loss enhances Schwann cell myelinating potential by altering mTOR signaling and enabling multiple axon myelination, challenging previous distinctions between myelinating and non-myelinating Schwann cells.