David Anthony Lyons

This paper identifies FABP8/PMP2 as a defining feature of human and old-world monkey CNS myelin, revealing molecular heterogeneity in myelin sheaths and its role in cholesterol enrichment.

This study shows that mislocalisation of TDP-43 to the cytoplasm in neurons or oligodendrocytes causes axonopathy and dysmyelination, highlighting the role of cell-type-specific loss of function in neurodegeneration.

The paper identifies 33 compounds that alter Mauthner axon diameter in zebrafish using a high-resolution imaging-based screen.

AQuA2 quantifies molecular spatiotemporal signals from live imaging data by decomposing complex datasets into signaling events, demonstrating applications across biosensors and cell types.

This study shows that CNS axon diameter growth does not require oligodendrocyte ensheathment or myelination, contrasting with PNS findings.

This study identifies FBXW7 as a regulator of myelin capacity and homeostasis in the adult CNS by controlling MYRF levels through ubiquitination.

The paper identifies importin 13b's role in axon diameter growth and shows its impact on conduction velocity in myelinated axons in zebrafish.

This study identifies a retroviral origin of vertebrate myelin by showing that RNLTR12-int retrotransposon regulates myelination through SOX10 interaction in multiple vertebrates.

This study shows that C9ORF72 deficiency in zebrafish causes retinal degeneration, including reduced thickness, gliosis, and neuronal loss, but not spinal cord pathology.

The paper identifies a conserved myelination mechanism in oligodendrocytes that forms paranodal bridges, enabling extended myelin sheaths along axons, which degenerate more frequently with age.

The paper compares remyelination by surviving and newly generated oligodendrocytes in MS, finding that newly generated cells produce more accurate and abundant myelin sheaths.

The paper shows that clusters of Neurofascin A on axons predict node of Ranvier positions before myelination, independent of myelin sheath growth.

This study shows that hypomyelination in zebrafish larvae disrupts axonal conduction and behavior, linking myelination to neural circuit function.

The paper uses synthetic CRISPR gRNAs and in vivo pre-screening to identify pro-regenerative genes in spinal cord injury, finding that tgfb1a promotes regeneration by controlling inflammation.

This study shows that TET1-mediated DNA hydroxy-methylation is essential for adult remyelination, with loss of function leading to impaired myelin repair in aged mice.

This study shows that disrupting NKCC1 in Schwann cells impairs their response to neuronal activity, leading to myelin defects and nerve pathology, which can be reversed by TTX treatment.

This study shows that Fbxw7 loss enhances Schwann cell myelinating potential by altering mTOR signaling and enabling multiple axon myelination, challenging previous distinctions between myelinating and non-myelinating Schwann cells.