Robert J. Eddy

This study identifies MenaINV as essential for breast cancer stem cell extravasation but not survival, revealing distinct pathways for metastatic dominance.

This study shows that Mena promotes KRAS-driven pancreatic tumor growth and metastasis by enhancing oncogenic signaling pathways.

This study identifies TMEM doorways as a mechanism for metastasis in PDAC, showing Tie2 macrophages facilitate intravasation and that targeting Tie2 improves survival in mouse models.

This study shows CXCL12 gradients around TMEM doorways promote tumor cell invasion and create immunosuppressive niches by affecting CD8+ T cell function and distribution.